Clinical Correlates of Cholestasis in Preterm Infants with Surgical Necrotizing Enterocolitis.

ABSTRACT:

Background

We sought to investigate the clinical determinants and outcomes of cholestasis in preterm infants with surgical necrotizing enterocolitis (sNEC).

Methods

Retrospective comparison of clinical information in preterm infants who developed cholestasis vs those who did not.

Results

Sixty-two (62/91, 68.1%) infants with NEC developed cholestasis at any time following the onset of illness. Cholestasis was seen more frequently in those who had received ionotropic support at 24 hours following sNEC diagnosis (87.1% vs 58.6%; p = 0.002), had higher mean C-reactive protein levels 2 weeks after NEC diagnosis (p = 0.009), had blood culture-positive sepsis [25 (40.3%) vs 4 (13.8%); p = 0.011], received parenteral nutrition (PN) for longer durations (

SUBMITTER: Garg PM 

PROVIDER: S-EPMC10653206 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature