Translational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state.

ABSTRACT: Trypanosoma brucei occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping of the protein landscape of the parasite both to evade surveillance and face changing metabolic demands. In kinetoplastid protozoa, including T. brucei, posttranscriptional control mechanisms are the primary means of gene regulation, and these are often mediated by RNA-binding proteins. DRBD18 is a T. brucei RNA-binding protein that reportedly interacts with ribosomal proteins and translation factors. Here, we tested a role for DRBD18 in translational control. We validate the DRBD18 interaction with translating ribosomes and the translation in

SUBMITTER: Ciganda M 

PROVIDER: S-EPMC10653379 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature