Distinct Alterations in Oxygenation, Ion Composition and Acid-Base Balance in Cerebral Collaterals During Large-Vessel Occlusion Stroke.

ABSTRACT:

Purpose

Disturbances of blood gas and ion homeostasis including regional hypoxia and massive sodium (Na⁺)/potassium (K⁺) shifts are a hallmark of experimental cerebral ischemia but have not been sufficiently investigated for their relevance in stroke patients.

Methods

We report a prospective observational study on 366 stroke patients who underwent endovascular thrombectomy (EVT) for large-vessel occlusion (LVO) of the anterior circulation (18 December 2018-31 August 2020). Intraprocedural blood gas samples (1 ml) from within cerebral collateral arteries (ischemic) and matched systemic control samples were obtained according to a prespecified protocol in 51 patients.

Results

We observed a significant reduction in cerebral oxygen partial pressure (

SUBMITTER: Feick J 

PROVIDER: S-EPMC10654170 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature