Unraveling Autonomic Dysfunction in GBA-Related Parkinson's Disease.

ABSTRACT:

Background

Patients with Parkinson's disease (PD) and GBA gene mutations (GBA-PD) develop nonmotor complications more frequently than noncarriers. However, an objective characterization of both cardiovascular and sudomotor autonomic dysfunction using extensive clinical and instrumental measures has never been provided so far. Survival is reduced in GBA-PD regardless of age and dementia, suggesting that other hitherto unrecognized factors are involved.

Objectives

To provide instrumental measures of pattern and severity of autonomic dysfunction in GBA-PD and explore their correlation with other non-motor symptoms and implications for clinical practice.

Methods

In this cross-sectional study, 21 GBA-PD and 24 matched PD noncarriers underwent extensive assessment of

SUBMITTER: Devigili G 

PROVIDER: S-EPMC10654845 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature