Silk fibroin, gelatin, and human placenta extracellular matrix-based composite hydrogels for 3D bioprinting and soft tissue engineering.

ABSTRACT:

Background

There is a great clinical need and it remains a challenge to develop artificial soft tissue constructs that can mimic the biomechanical properties and bioactivity of natural tissue. This is partly due to the lack of suitable biomaterials. Hydrogels made from human placenta offer high bioactivity and represent a potential solution to create animal-free 3D bioprinting systems that are both sustainable and acceptable, as placenta is widely considered medical waste. A combination with silk and gelatin polymers can bridge the biomechanical limitations of human placenta chorion extracellular matrix hydrogels (hpcECM) while maintaining their excellent bioactivity.

Method

In this study, silk fibroin (SF) and tyramine-substituted gelatin (G-TA) were enzymatically crosslink

SUBMITTER: Schneider KH 

PROVIDER: S-EPMC10656895 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature