The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling.

ABSTRACT: The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its timing remain elusive. We show that the transcriptional regulator DVE-1, which shares homology with special AT-rich sequence-binding (SATB) family members previously implicated in human neurodevelopmental disorders, directs the elimination of juvenile synaptic inputs onto remodeling C. elegans GABAergic neurons. Juvenile acetylcholine receptor clusters and apposing presynaptic sites are eliminated during the maturation of wild-type GABAergic neurons but persist into adulthood in dve-1 mutants, producing heightened motor connectivity. DVE-1 localization to GABAergic nuclei is required for synapse elimination, consistent with DVE-1 re

SUBMITTER: Alexander KD 

PROVIDER: S-EPMC10657367 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature