Immune senescence in aged APP/PS1 mice.

ABSTRACT:

Objectives

To evaluate the linkage between age and deficits in innate and adaptive immunity which heralds both Alzheimer's disease (AD) onset and progression. The pathobiological events which underlie and tie these outcomes remain not fully understood.

Methods

To investigate age-dependent immunity in AD, we evaluated innate and adaptive immunity in coordinate studies of regulatory T cell (Treg) function, T cell frequencies, and microglial integrity. These were assessed in blood, peripheral lymphoid tissues, and the hippocampus of transgenic (Tg) amyloid precursor protein/presenilin 1 (APP/PS1) against non-Tg mice. Additionally, immune arrays of hippocampal tissue were performed at 4, 6, 12, and 20 months of age.

Results

APP/PS1 mice showed progressive impairment of Tr

SUBMITTER: Abdelmoaty MM 

PROVIDER: S-EPMC10659760 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature