Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry.

ABSTRACT:

Background

Different patient clusters were preliminarily suggested to dissect the clinical heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters in a multicentre, observational, prospective study to stratify these patients.

Methods

Patients included in GIRRCS AOSD-study group and AIDA Network Still Disease Registry were assessed if variables for cluster analysis were available (age, systemic score, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and ferritin). K-means algorithm with Euclidean metric and Elbow plot were used to derive an adequate number of clusters.

Results

K-means clustering assessment provided four clusters based on means standardised according to z-scores on 349 patients. All clusters mainly pres

SUBMITTER: Ruscitti P 

PROVIDER: S-EPMC10660445 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature