Vitamin B₅ supports MYC oncogenic metabolism and tumor progression in breast cancer.

ABSTRACT: Tumors are intrinsically heterogeneous and it is well established that this directs their evolution, hinders their classification and frustrates therapy^1-3. Consequently, spatially resolved omics-level analyses are gaining traction^4-9. Despite considerable therapeutic interest, tumor metabolism has been lagging behind this development and there is a paucity of data regarding its spatial organization. To address this shortcoming, we set out to study the local metabolic effects of the oncogene c-MYC, a pleiotropic transcription factor that accumulates with tumor progression and influences metabolism^10,11. Through correlative mass spectrometry imaging, we show that pantothenic acid (vitamin B₅) associates with MYC-high areas within both human and mu

SUBMITTER: Kreuzaler P 

PROVIDER: S-EPMC10663155 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature