An essential role for miR-15/16 in Treg suppression and restriction of proliferation.

ABSTRACT: The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells to mediate a sustained response. Here, we used conditional deletion of miR-15/16 in regulatory T cells (Tregs) to identify immune functions of the miR-15/16 family in T cells. miR-15/16 are indispensable to maintain peripheral tolerance by securing efficient suppression by a limited number of Tregs. miR-15/16 deficiency alters expression of critical Treg proteins and results in accumulation of functionally impaired FOXP3^loCD25^loCD127^hi Tregs. Excessive proliferation in the absence of miR-15/16 shifts Treg fate and produce

SUBMITTER: Johansson K 

PROVIDER: S-EPMC10664750 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature