Ontology highlight
ABSTRACT:
SUBMITTER: Johansson K
PROVIDER: S-EPMC10664750 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Johansson Kristina K Gagnon John D JD Zhou Simon K SK Fassett Marlys S MS Schroeder Andrew W AW Kageyama Robin R Bautista Rodriel A RA Pham Hewlett H Woodruff Prescott G PG Ansel K Mark KM
Cell reports 20231019 10
The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells to mediate a sustained response. Here, we used conditional deletion of miR-15/16 in regulatory T cells (Tregs) to identify immune functions of the miR-15/16 family in T cells. miR-15/16 are indispensable to maintain peripheral tolerance by securing efficient s ...[more]