Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC10665915 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Xu Xiaoding X Yu Chuwei C He Hongxiu H Pan Xiangyu X Hou Aijun A Feng Jianxun J Tan Rongrong R Gong Likun L Chen Jing J Ren Jin J
iScience 20231028 11
Epigenetic regulations play crucial roles in the pathogenesis of metabolic-associated fatty liver disease; therefore, elucidating the biological functions of differential miRNAs helps us to understand the pathogenesis. Herein, we discovered miR-337-3p was decreased in patients with NAFLD from Gene Expression Omnibus dataset, which was replicated in various cell and mouse models with lipid disorders. Subsequently, overexpression of miR-337-3p <i>in vivo</i> could ameliorate hepatic lipid accumula ...[more]