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MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.


ABSTRACT: Epigenetic regulations play crucial roles in the pathogenesis of metabolic-associated fatty liver disease; therefore, elucidating the biological functions of differential miRNAs helps us to understand the pathogenesis. Herein, we discovered miR-337-3p was decreased in patients with NAFLD from Gene Expression Omnibus dataset, which was replicated in various cell and mouse models with lipid disorders. Subsequently, overexpression of miR-337-3p in vivo could ameliorate hepatic lipid accumulation, reduce fasting blood glucose, and improve insulin resistance. Meanwhile, we determined miR-337-3p might influence multiple genes involved in glycolipid metabolism through mass spectrometry detection, bioinformatics analysis, and experimental verification. Finally, we selected HMGCR as a representative example to investigate the molecular mechanism of miR-337-3p regulating these genes, where the seed region of miR-337-3p bound to 3'UTR of HMGCR to inhibit HMGCR translation. In conclusion, we discovered a new function of miR-337-3p in glycolipid metabolism and that might be a new therapeutic target of MAFLD.

SUBMITTER: Xu X 

PROVIDER: S-EPMC10665915 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.

Xu Xiaoding X   Yu Chuwei C   He Hongxiu H   Pan Xiangyu X   Hou Aijun A   Feng Jianxun J   Tan Rongrong R   Gong Likun L   Chen Jing J   Ren Jin J  

iScience 20231028 11


Epigenetic regulations play crucial roles in the pathogenesis of metabolic-associated fatty liver disease; therefore, elucidating the biological functions of differential miRNAs helps us to understand the pathogenesis. Herein, we discovered miR-337-3p was decreased in patients with NAFLD from Gene Expression Omnibus dataset, which was replicated in various cell and mouse models with lipid disorders. Subsequently, overexpression of miR-337-3p <i>in vivo</i> could ameliorate hepatic lipid accumula  ...[more]

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