Ontology highlight
ABSTRACT:
SUBMITTER: Adly AN
PROVIDER: S-EPMC10665939 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Adly Armin N AN Bi Maxine M Carlson Christopher R CR Syed Abdullah M AM Ciling Alison A Doudna Jennifer A JA Cheng Yifan Y Morgan David O DO
The Journal of biological chemistry 20231019 12
The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein serine/arginine (SR) region. Several SARS-CoV-2 variants of concern carry N protein mutations that reduce phosphorylation and enhance the efficiency of viral packaging. Variants of the dominant B.1.1 viral lineage also encode a truncated N protein, terme ...[more]