Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity.

ABSTRACT:

Background

Viral infections, especially those caused by rhinovirus, are the most common cause of asthma exacerbations. Previous studies have argued that impaired innate antiviral immunity and, as a consequence, more severe infections contribute to these exacerbations.

Objective

These studies explored the innate immune response in the upper airway of volunteers with allergic rhinitis and asthma in comparison to healthy controls and interrogated how these differences corresponded to severity of infection.

Methods

Volunteers with allergic rhinitis, those with asthma, and those who are healthy were inoculated with rhinovirus A16 and monitored for clinical symptoms. Tissue and nasal wash samples were evaluated for antiviral signature and viral load.

Results

Both sub

SUBMITTER: Feng X 

PROVIDER: S-EPMC10666001 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature