Dataset Information

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

ABSTRACT:

Background

A significant link between T allele of the IL-4 (C590T) gene and developing asthma in some populations was reported. However, no study discussed the link between IL-4 (C590T) gene polymorphism and asthma severity groups (mild and severe). This study investigated the link between IL-4 gene variation and asthma severity.

Methods

The study included 215 asthmatic patients, of which 102 had mild asthma, and 126 participants were healthy controls. A previously published polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to identify various IL-4 (C590T) gene polymorphism genotypes.

Results

The T allele frequency was higher in mild asthma (p=0.002) but not in severe asthma (p=0.12) compared to controls. In mild asthma, the CT genotype and (CT+TT versus CC) increased the likelihood of asthma threefold (p<0.001, 0.001). However, no significant association with severe asthma was found in either genetic model. Stratification analysis showed that the C allele and CC genotype increased the risk of severe asthma (p=0.01). The recessive genetic model indicated a decrease in the risk of severe asthma (OR=0.5, p=0.01) in the non-adjusted regression analysis. Adjusting for age, sex, and other risk factors revealed that the IL-4 gene polymorphism did not influence the risk of severe asthma (OR=0.92, p=0.80); however, being an elderly female with a history of childhood-onset disease and associated nasal polyp (NP) increased the likelihood of severe asthma, OR=1.08, 2.01, 2.36, 8.42; p<0.001, 0.05, 0.05, <0.001, respectively.

Conclusion

The T allele and CT genotype in the co-dominant genetic model and the (CT+TT) genotype in the recessive model were found to have a higher likelihood of developing mild asthma but not severe asthma; severe asthma was found to be higher in elderly females with a history of childhood-onset disease and associated nasal polyps.

SUBMITTER: Al-Ahmad M

PROVIDER: S-EPMC10676224 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

Al-Ahmad Mona M Ali Asmaa A Haider Mohammad Z MZ

Journal of asthma and allergy 20231121

<h4>Background</h4>A significant link between T allele of the <i>IL-4</i> (C590T) gene and developing asthma in some populations was reported. However, no study discussed the link between <i>IL-4</i> (C590T) gene polymorphism and asthma severity groups (mild and severe). This study investigated the link between <i>IL-4</i> gene variation and asthma severity.<h4>Methods</h4>The study included 215 asthmatic patients, of which 102 had mild asthma, and 126 participants were healthy controls. A previ ...[more]

PMID: 38022750

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Dataset Information

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

Background

Methods

Results

Conclusion

Publications

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

Similar Datasets

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