Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

ABSTRACT:

Background

A significant link between T allele of the IL-4 (C590T) gene and developing asthma in some populations was reported. However, no study discussed the link between IL-4 (C590T) gene polymorphism and asthma severity groups (mild and severe). This study investigated the link between IL-4 gene variation and asthma severity.

Methods

The study included 215 asthmatic patients, of which 102 had mild asthma, and 126 participants were healthy controls. A previously published polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to identify various IL-4 (C590T) gene polymorphism genotypes.

Results

The T allele frequency was higher in mild asthma (p=0.002) but not in severe asthma (p=0.12) compared to c

SUBMITTER: Al-Ahmad M 

PROVIDER: S-EPMC10676224 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature