Migraine and major depression: localizing shared genetic susceptibility in different cell types of the nervous systems.

ABSTRACT:

Background

There is a bidirectional relationship between migraine and major depression disorder (MDD). They likely share important risk genes associated with different cell types in the central nervous system (CNS) and peripheral nervous system (PNS). Profiling the expression of these genes in specific cell types is critical in understanding the pathophysiology of the relationship between migraine and MDD.

Methods

Associated genes shared by migraine and MDD were identified by consolidating multiple curations of human disease-gene associations. Subsequently, the expression of overlapping genes was profiled and compared across the different cell types in CNS, PNS and neurovascular cells using eight single cell RNA sequencing datasets, including two human CNS datasets, two mous

SUBMITTER: Androulakis XM 

PROVIDER: S-EPMC10684773 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature