Survextrap: a package for flexible and transparent survival extrapolation.

ABSTRACT:

Background

Health policy decisions are often informed by estimates of long-term survival based primarily on short-term data. A range of methods are available to include longer-term information, but there has previously been no comprehensive and accessible tool for implementing these.

Results

This paper introduces a novel model and software package for parametric survival modelling of individual-level, right-censored data, optionally combined with summary survival data on one or more time periods. It could be used to estimate long-term survival based on short-term data from a clinical trial, combined with longer-term disease registry or population data, or elicited judgements. All data sources are represented jointly in a Bayesian model. The hazard is modelled as an M-spline

SUBMITTER: Jackson CH 

PROVIDER: S-EPMC10685663 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature