A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.

ABSTRACT:

Background

Irritability, defined as proneness to anger, can reach a pathological extent. It is a defining symptom of disruptive mood dysregulation disorder and one of the most common reasons youths present for psychiatric evaluation and care. Aberrant responses to frustrative nonreward (FNR), the response to omission of expected reward, are central to the pathophysiology of irritability. FNR is a translational construct to study irritability across species. The development of preclinical FNR models would advance mechanistic studies of the important and relatively understudied clinical phenomenon of irritability.

Methods

We used FNR as a conceptual framework to develop a novel mouse behavioral paradigm named alternate poking reward omission. Juvenile mice were exposed to alte

SUBMITTER: Naik AA 

PROVIDER: S-EPMC10689275 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature