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Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes.

ABSTRACT: Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp³)-C(sp³) bond and one C(sp³)-C(sp²) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.

SUBMITTER: Gao Y

PROVIDER: S-EPMC10689762 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes.

Gao Yuxi Y Gao Lijuan L Zhu Endiao E Yang Yunhong Y Jie Mi M Zhang Jiaqian J Pan Zhiqiang Z Xia Chengfeng C

Nature communications 20231130 1

Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp3)-C(sp3) bond and one C(sp3)-C(sp2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enan ...[more]

PMID: 38036527

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