Mechanisms of transcriptional regulation in <i>Anopheles gambiae</i> revealed by allele specific expression.

ABSTRACT: Malaria control relies on insecticides targeting the mosquito vector, but this is increasingly compromised by insecticide resistance, which can be achieved by elevated expression of detoxifying enzymes that metabolize the insecticide. In diploid organisms, gene expression is regulated both in cis, by regulatory sequences on the same chromosome, and by trans acting factors, affecting both alleles equally. Differing levels of transcription can be caused by mutations in cis-regulatory modules (CRM), but few of these have been identified in mosquitoes. We crossed bendiocarb resistant and susceptible Anopheles gambiae strains to identify cis-regulated genes that might be responsible for the resistant phenotype using RNAseq, and cis-regulatory module seq

SUBMITTER: Dyer NA 

PROVIDER: S-EPMC10690255 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature