Sex differences in brain transcriptomes of juvenile Cynomolgus macaques.

ABSTRACT:

Background

Behavioral, social, and physical characteristics are posited to distinguish the sexes, yet research on transcription-level sexual differences in the brain is limited. Here, we investigated sexually divergent brain transcriptomics in prepubertal cynomolgus macaques, a commonly used surrogate species to humans.

Methods

A transcriptomic profile using RNA sequencing was generated for the temporal lobe, ventral midbrain, and cerebellum of 3 female and 3 male cynomolgus macaques previously treated with an Adeno-associated virus vector mix. Statistical analyses to determine differentially expressed protein-coding genes in all three lobes were conducted using DeSeq2 with a false discovery rate corrected P value of .05.

Results

We identified target genes in the temp

SUBMITTER: Kabbej N 

PROVIDER: S-EPMC10690328 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature