Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.

ABSTRACT:

Background

Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of sepsis. In addition, sepsis survivors often suffer from persisting memory deficits and impaired executive functions. Recent studies provide evidence that microglia are involved in the pathophysiology of SAE.

Methods

Here, we investigated whether pharmacological depletion of microglia using PLX5622 (1200 ppm or 300 ppm) in the acute phase of sepsis is able to prevent long-term neurocognitive decline in a male mouse model of polymicrobial sepsis or lipopolysaccharide-induced sterile neuroinflammation. Therefore, we performed the novel object recognition test at d

SUBMITTER: Mein N 

PROVIDER: S-EPMC10691003 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature