Dataset Information

Headaches during pregnancy and the risk of subsequent stroke.

ABSTRACT:

Background

Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pregnancy. However, despite this, some women develop headaches during pregnancy (G-HA), and the effect of this headache on subsequent stroke is unknown. In this study, we evaluated the association between G-HA and stroke after delivery in women.

Methods

Based on the Korean National Health Insurance Service database, we included women hospitalized for delivery between 2012 and 2013. G-HA was defined as a headache diagnosed during pregnancy. Primary outcome was any stroke that occurred during the observational periods from delivery to December 31, 2020. All diseases were identified based on data registered in the database using the International Classification of Disease-10^th Revision-Clinical Modification codes.

Results

Of 906,187 pregnant women, G-HA was found in 56,813 (6.3%). During the observational periods, the G-HA ( +) group had a significantly higher risk of any stroke [adjusted hazard ratio (aHR) = 1.59, 95% confidence interval (CI): 1.30-1.95], ischemic stroke (aHR = 1.50, 95% CI: 1.12-2.01), hemorrhagic stroke (aHR = 1.63, 95% CI: 1.23-2.15), and intracerebral hemorrhage (aHR = 1.63, 95% CI: 1.19-2.23) than the G-HA (-) group. When analyzed considering the interaction with history of headache disorder, G-HA showed a significant association with hemorrhagic stroke, but lost its effect on ischemic stroke.

Conclusions

We demonstrated that G-HA was associated with subsequent stroke occurrence after delivery. However, the relationship between G-HA and ischemic stroke is mitigated by a history of pre-pregnancy headache disorder.

SUBMITTER: Nam KW

PROVIDER: S-EPMC10691126 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Headaches during pregnancy and the risk of subsequent stroke.

Nam Ki-Woong KW Ha Sungyeon S Oh Min-Jeong MJ Oh Kyungmi K Kim Chi Kyung CK Cho Geum Joon GJ Kim Young Seo YS Bushnell Cheryl D CD

The journal of headache and pain 20231201 1

<h4>Background</h4>Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pregnancy. However, despite this, some women develop headaches during pregnancy (G-HA), and the effect of this headache on subsequent stroke is unknown. In this study, we evaluated the association between G-HA and stroke after delivery in women.<h4>Methods</h4>Based on the Korean National Health Insurance Service database, we included women hospitalized for d ...[more]

PMID: 38041004

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Dataset Information

Headaches during pregnancy and the risk of subsequent stroke.

Background

Methods

Results

Conclusions

Publications

Headaches during pregnancy and the risk of subsequent stroke.

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