MicroRNA-155 targets SOCS1 to inhibit osteoclast differentiation during orthodontic tooth movement.

ABSTRACT:

Background

MicroRNA-155 (miR-155) is a multifunctional miRNA whose expression is known to be involved in a range of physiological and pathological processes. Its association with several oral diseases has been established. However, the specific role of miR-155 in orthodontic tooth movement remains unclear. In this study, we investigated the impact of miR-155 on osteoclast differentiation and orthodontic tooth movement models, aiming to explore the underlying mechanisms.

Methods

In this experiment, we utilized various agents including miR-155 mimic, miR-155 inhibitor, as well as non-specific sequences (NC mimic & NC inhibitor) to treat murine BMMNCs. Subsequently, osteoclast induction (OC) was carried out to examine the changes in the differentiation ability of monocytes unde

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC10693016 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature