Lung-heart toxicity in a randomized clinical trial of hypofractionated image guided radiation therapy for breast cancer.

ABSTRACT:

Background

TomoBreast hypothesized that hypofractionated 15 fractions/3 weeks image-guided radiation therapy (H-IGRT) can reduce lung-heart toxicity, as compared with normofractionated 25-33 fractions/5-7 weeks conventional radiation therapy (CRT).

Methods

In a single center 123 women with stage I-II operated breast cancer were randomized to receive CRT (N=64) or H-IGRT (N=59). The primary endpoint used a composite four-items measure of the time to 10% alteration in any of patient-reported outcomes, physician clinical evaluation, echocardiography or lung function tests, analyzed by intention-to-treat.

Results

At 12 years median follow-up, overall and disease-free survivals between randomized arms were comparable, while survival time free from alteration significantly

SUBMITTER: Van Parijs H 

PROVIDER: S-EPMC10694354 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature