Dataset Information

Arm swing asymmetry in people with Parkinson's disease and its relationship with gait: A systematic review and meta-analysis.

ABSTRACT:

Background

Individuals with Parkinson's disease present arm swing alterations that can adversely affect their locomotion.

Objective

To identify differences in arm swing asymmetry (ASA) between individuals with Parkinson's disease (PD) and healthy individuals and to investigate the relationship between ASA, temporal-spatial gait parameters, and disease progression.

Methods

A literature search was conducted in PubMed, Scopus, ProQuest, Web of Science, and EBSCOhost up to February 2023. Cross-sectional studies evaluating parameters of arm swing (AS) and ASA were included. Methodological quality was assessed using the Critical Appraisal Checklist, and the quality of the evidence was measured with a modified Grading of Recommendations Assessment, Development, and Evaluation.

Results

Fourteen studies were included in the systematic review (1130 participants). Irrespective of the medication phase (ON or OFF) and the type of walk test employed, the meta-analysis showed moderate-quality evidence that individuals with PD have increased ASA amplitude (SMD = 0.84; 95% CI: 0.69, 0.99; I²= 0%).Very low-quality evidence suggests higher ASA velocity (SMD=0.64; 95% CI: 0.24, 1.05; I²=59%) and lower AS amplitude on both the most affected (ES = -1.99, 95% CI: -3.04, -0.94, I²: 91%) and the least affected sides (ES = -0.75, 95% CI: -1.05, -0.44; I²=66%). Meta-regression indicated that ASA is inversely related to disease duration (Z: -2.4892, P< 0.05) and motor symptoms progression (Z: -2.1336, P< 0.05).

Conclusions

Regardless of the medication phase and the type of walk test employed, individuals with PD exhibited greater ASA and decreased AS amplitude than healthy individuals. ASA decreases as the disease progresses and symptoms worsen.

SUBMITTER: Espinoza-Araneda J

PROVIDER: S-EPMC10695845 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature

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Publications

Arm swing asymmetry in people with Parkinson's disease and its relationship with gait: A systematic review and meta-analysis.

Espinoza-Araneda Jessica J Caparrós-Manosalva Cristian C Caballero Paula M PM da Cunha Maira J MJ Marchese Ritchele R RR Pagnussat Aline S AS

Brazilian journal of physical therapy 20231107 6

<h4>Background</h4>Individuals with Parkinson's disease present arm swing alterations that can adversely affect their locomotion.<h4>Objective</h4>To identify differences in arm swing asymmetry (ASA) between individuals with Parkinson's disease (PD) and healthy individuals and to investigate the relationship between ASA, temporal-spatial gait parameters, and disease progression.<h4>Methods</h4>A literature search was conducted in PubMed, Scopus, ProQuest, Web of Science, and EBSCOhost up to Febr ...[more]

PMID: 37980716

Similar Datasets

Project description:BackgroundAccurately measuring hypokinetic arm swing during free-living gait in Parkinson's disease (PD) is challenging due to other concurrent arm activities. We developed a method to isolate gait segments without these arm activities.MethodsWrist accelerometer and gyroscope data were collected from 25 individuals with PD and 25 age-matched controls while performing unscripted activities in their home environment. This was done after overnight withdrawal of dopaminergic medication ('pre-medication') and approximately one hour after intake ('post-medication'). Using video annotations as ground truth, we trained and evaluated two classifiers: one for detecting gait and one for detecting gait segments without other arm activities. Based on the filtered gait segments, arm swing was quantified using the median and 95th percentile range of motion (RoM). These arm swing parameters were evaluated in three ways: (1) the agreement between predicted and video-annotated gait segments without other arm activities, (2) the sensitivity to differences between PD and controls, and (3) the sensitivity to the effects of dopaminergic medication.ResultsOn the most affected side, the mean (SD) balanced accuracy for detecting gait without other arm activities was 0.84 (0.10) pre-medication and 0.88 (0.09) post-medication. The agreement between arm swing parameters of predicted and video-annotated gait segments without other arm activities was high irrespective of medication state (intra-class correlation coefficients: median RoM: 0.99; 95th percentile RoM: 0.97). Both the median and 95th percentile RoM were smaller in PD pre-medication compared to controls (median: Δ = - 18 . 80 ∘ , 95% CI [ - 30.63, - 10.60], p < 0.001; 95th percentile: Δ = - 28 . 34 ∘ , 95% CI [ - 38.26, - 18.18], p < 0.001), and smaller in pre- compared to post-medication (median: Δ = - 12 . 31 ∘ , 95% CI [ - 21.35, - 5.59], p < 0.001; 95th percentile: Δ = - 19 . 04 ∘ , 95% CI [ - 28.48, - 11.14], p < 0.001). The differences in RoM between pre- and post-medication were larger after filtering gait for the median (p < 0.01) and 95th percentile RoM (p = 0.01).ConclusionsFiltering out gait segments with other concurrent arm activities is feasible and increases the change in arm swing parameters following dopaminergic medication in free-living conditions. This approach may be used to monitor treatment effect and disease progression in daily life.

Dataset Information

Arm swing asymmetry in people with Parkinson's disease and its relationship with gait: A systematic review and meta-analysis.

Background

Objective

Methods

Results

Conclusions

Publications

Arm swing asymmetry in people with Parkinson's disease and its relationship with gait: A systematic review and meta-analysis.

Similar Datasets

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