Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years.

ABSTRACT: Major Depressive Disorder (MDD) often is a recurrent and chronic disorder. We investigated the neurocognitive underpinnings of the incremental risk for poor disease course by exploring relations between enduring depression and brain functioning during regulation of negative and positive emotions using cognitive reappraisal. We used fMRI-data from the longitudinal Netherlands Study of Depression and Anxiety acquired during an emotion regulation task in 77 individuals with MDD. Task-related brain activity was related to disease load, calculated from presence and severity of depression in the preceding nine years. Additionally, we explored task related brain-connectivity. Brain functioning in individuals with MDD was further compared to 35 controls to explore overlap between load-effects and

SUBMITTER: van Kleef RS 

PROVIDER: S-EPMC10696117 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature