Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology.

ABSTRACT:

Objective

To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.

Research design and methods

A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 ± 7.5) years with available data on brain MRI and blood HbA1c levels was analyzed. The relationship between HbA1c and CT was probed using independent spatial profiles of cell-specific gene expression. Lastly, a genome-wide association study was conducted on the shared variance between HbA1c and CT.

Results

The HbA1c-CT association was noncontinuous, emerging negatively within the prediabetic range (39.6 mmol/mol). This association was strongest in brain regions with higher expression of genes specific to excitatory n

SUBMITTER: Shin J 

PROVIDER: S-EPMC10698225 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature