Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology.
Ontology highlight
ABSTRACT: Objective
To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.Research design and methods
A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 ± 7.5) years with available data on brain MRI and blood HbA1c levels was analyzed. The relationship between HbA1c and CT was probed using independent spatial profiles of cell-specific gene expression. Lastly, a genome-wide association study was conducted on the shared variance between HbA1c and CT.Results
The HbA1c-CT association was noncontinuous, emerging negatively within the prediabetic range (39.6 mmol/mol). This association was strongest in brain regions with higher expression of genes specific to excitatory neurons and lower expression of genes specific to astrocytes and microglia. A significant locus implicated mitochondrial maintenance and ATP generation.Conclusions
Effective glycemia control at prediabetic levels is warranted to preserve brain health and prevent prediabetes-related neurobiologic perturbations.
SUBMITTER: Shin J
PROVIDER: S-EPMC10698225 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology.
Shin Jean J Patel Yash Y Parker Nadine N Paus Tomas T Pausova Zdenka Z
Diabetes care 20231201 12
<h4>Objective</h4>To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.<h4>Research design and methods</h4>A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 ± 7.5) years with available data on brain MRI and blood HbA1c levels was analyzed. The relationship between HbA1c and CT was probed using independent spatial profiles of cell-specific gene expression. Lastly, a genome-wide associ ...[more]
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