Immunotherapies inducing immunogenic cell death in cancer: insight of the innate immune system.

ABSTRACT: Cancer immunotherapies include monoclonal antibodies, cytokines, oncolytic viruses, cellular therapies, and other biological and synthetic immunomodulators. These are traditionally studied for their effect on the immune system's role in eliminating cancer cells. However, some of these therapies have the unique ability to directly induce cytotoxicity in cancer cells by inducing immunogenic cell death (ICD). Unlike general immune stimulation, ICD triggers specific therapy-induced cell death pathways, based on the release of damage-associated molecular patterns (DAMPs) from dying tumour cells. These activate innate pattern recognition receptors (PRRs) and subsequent adaptive immune responses, offering the promise of sustained anticancer drug efficacy and durable antitumour immune memory. Expl

SUBMITTER: Calvillo-Rodriguez KM 

PROVIDER: S-EPMC10701401 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature