Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles.

ABSTRACT:

Introduction

The HLA region is the hallmark of balancing selection, argued to be driven by the pressure to present a wide variety of viral epitopes. As such selection on the peptide-binding positions has been proposed to drive HLA population genetics. MHC molecules also directly binds to the T-Cell Receptor and killer cell immunoglobulin-like receptors (KIR).

Methods

We here combine the HLA allele frequencies in over six-million Hematopoietic Stem Cells (HSC) donors with a novel machine-learning-based method to predict allele frequency.

Results

We show for the first time that allele frequency can be predicted from their sequences. This prediction yields a natural measure for selection. The strongest selection is affecting KIR binding regions, followed by the peptide-b

SUBMITTER: Levi R 

PROVIDER: S-EPMC10703150 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature