Mycobacterium ulcerans-Bordetella trematum chronic tropical cutaneous ulcer: A four-case series, Cote d'Ivoire.

ABSTRACT:

Background

Chronic tropical cutaneous ulcers remain a neglected medical condition in West Africa, particularly Buruli ulcer, which is caused by mycolactone cytotoxin-secreting Mycobacterium ulcerans (M. ulcerans). Medical management of this highly debilitating and necrotising skin infection may be modified by colonisation and co-infection of the ulcer by opportunistic and pathogenic microorganisms, which considerably delays and increases the cost of treatment.

Methodology/principal finding

We diagnosed chronic tropical cutaneous ulcers in nine patients in Côte d'Ivoire using M. ulcerans-specific PCRs and culturomics. This revealed M. ulcerans in 7/9 ulcer swabs and 5/9 control swabs as well as an additional 122 bacterial species, 32 of which were specific to ulcers, 61 speci

SUBMITTER: Tchan BGO 

PROVIDER: S-EPMC10703317 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature