Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma.

ABSTRACT:

Background

Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, MYC is difficult to target because of its undruggable structure. We aimed to uncover MYC-associated molecular targets to provide new strategies for LIHC treatment.

Methods

LIHC transcriptome datasets and clinical information were obtained from The Cancer Genome Atlas. A series of bioinformatics analyses were performed for 370 patients who were stratified based on the median MYC expression level (high-MYC group and low-MYC group). Correlation analysis was performed to determine relationships between the expression of key MYC-associated genes and prognosis, DNA promotor methylation, and immune cell infiltration. Gene ontology and Kyoto Encyclopedia of Genes and Ge

SUBMITTER: Li S 

PROVIDER: S-EPMC10703616 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature