Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota.

ABSTRACT: The gut-brain axis is a bidirectional communication system between the gut and central nervous system. Many host-related factors can affect gut microbiota, including oral bacteria, making the brain a vulnerable target via the gut-brain axis. Saliva contains a large number of oral bacteria, and periodontitis, a common oral disease, can change the composition of salivary microbiota. However, the role and mechanism of periodontitis salivary microbiota (PSM) on the gut-brain axis remain unclear. Herein, we investigated the nature and mechanisms of this relationship using the mice with dextran sulfate sodium salt (DSS)-induced anxiety-like behavior. Compared with healthy salivary microbiota, PSM worsened anxiety-like behavior; it significantly reduced the number of normal neurons and activated

SUBMITTER: Qian J 

PROVIDER: S-EPMC10703887 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature