Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor.

ABSTRACT: The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated. Here we found that nerve growth factor (NGF) produced by leptin receptor-expressing (LepR⁺) stromal cells is required to maintain nerve fibres in adult bone marrow. In nerveless bone marrow, steady-state haematopoiesis was normal but haematopoietic and vascular regeneration were impaired after myeloablation. LepR⁺ cells, and the adipocytes they gave rise to, increased NGF production after myeloablation, promoting nerve sprouting in the bone marrow and haematopoietic and vascular regeneration. Nerves promoted regeneration by activating β2 and β3 adrenergic receptor signalling in LepR

SUBMITTER: Gao X 

PROVIDER: S-EPMC10709146 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature