Dataset Information

Real-world first-line afatinib for advanced EGFR mutation-positive non-small cell lung cancer in Korea: updated survival data.

ABSTRACT:

Background

Data from clinical trials and real-world studies show that afatinib is effective in treating non-small cell lung cancer (NSCLC) harboring activating mutations in the epidermal growth factor receptor (EGFR) gene. A previous analysis of patients enrolled in the Korean Academy of Tuberculosis and Respiratory Disease (KATRD) EGFR cohort showed that first-line afatinib was well tolerated and effectiveness results were encouraging. At the time of the previous analysis, survival data were not mature. Here we briefly present updated survival data from the cohort.

Methods

The study was a retrospective, multicenter (15 sites) review of electronic records of Korean adult patients (aged >20 years) with advanced EGFR mutation-positive NSCLC who initiated first-line afatinib (N=421). Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier survival curves.

Results

Overall, median PFS was 20.2 months and median OS was 48.6 months. OS rates at 36 and 60 months were 60.1% and 42.3%, respectively. Presence vs. absence of baseline brain metastases was associated with significantly reduced median PFS (14.9 vs. 28.0 months; P<0.001) and median OS (32.2 vs. 65.6 months; P<0.001). The presence of common baseline EGFR mutations (Del19, L858R) was associated with significantly prolonged median OS (49.6 vs. 30.1 months; P=0.017). In patients stratified by the presence/absence of T790M EGFR mutation, the T790M mutation was associated with significantly reduced median PFS (P=0.0005) but there was no significant difference between groups in survival (P=0.263). There were no significant differences in PFS or OS for patients stratified by afatinib dose reduction or by age group (<70 vs. ≥70 years).

Conclusions

Afatinib was effective in Korean patients with EGFR mutation-positive NSCLC with median OS over 4 years. The presence of baseline brain metastases and/or uncommon EGFR mutations were associated with reduced survival. In the absence of baseline brain metastases, median OS was more than 5 years.

SUBMITTER: Choi J

PROVIDER: S-EPMC10713275 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Real-world first-line afatinib for advanced <i>EGFR</i> mutation-positive non-small cell lung cancer in Korea: updated survival data.

Choi Juwhan J Choi Chang Min CM Chang Yoon Soo YS Lee Kye Young KY Kim Seung Joon SJ Yang Sei Hoon SH Ryu Jeong Seon JS Lee Jeong Eun JE Lee Shin Yup SY Park Ji Young JY Kim Young-Chul YC Oh In-Jae IJ Jung Chi Young CY Lee Sang Hoon SH Yoon Seong Hoon SH Lee Sung Yong SY Jang Tae Won TW

Translational lung cancer research 20231128 11

<h4>Background</h4>Data from clinical trials and real-world studies show that afatinib is effective in treating non-small cell lung cancer (NSCLC) harboring activating mutations in the epidermal growth factor receptor (<i>EGFR</i>) gene. A previous analysis of patients enrolled in the Korean Academy of Tuberculosis and Respiratory Disease (KATRD) <i>EGFR</i> cohort showed that first-line afatinib was well tolerated and effectiveness results were encouraging. At the time of the previous analysis, ...[more]

PMID: 38090523

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