Dataset Information

Real-world experience of afatinib as first-line therapy for advanced EGFR mutation-positive non-small cell lung cancer in Korea.

ABSTRACT:

Background

We investigated the clinical characteristics and treatment outcomes of Korean patients receiving first-line afatinib for advanced epidermal growth factor receptor mutation-positive (EGFRm⁺) non-small cell lung cancer (NSCLC) in a real-world setting.

Methods

Electronic case reports were retrospectively reviewed from patients across 15 sites in South Korea. Outcome measures included baseline characteristics, overall response rate (ORR), time-to-treatment discontinuation (TTD), and overall survival (OS). Subgroups were: presence/absence of brain metastases at baseline, dose reductions, and baseline EGFR mutation category.

Results

Among 422 patients, 39.8% had brain metastases and 59.0%/25.1%/10.0%/5.0% had Del19/L858R/compound/uncommon EGFR mutations at baseline. ORR was 62.6% overall; responses were observed across all EGFR mutation categories, including against compound mutations. Median TTD was 17.8 months; median OS was not reached (NR). Median TTD and OS were longer in patients without versus with brain metastases (TTD: 22.9 vs. 14.8 months, P=0.001; OS: NR vs. 40.3 months, P=0.0009) and patients with versus without dose reductions (TTD: 22.2 vs. 14.2 months, P=0.0004; OS: NR vs. 40.3 months, P=0.0117). Median OS was 30.5/37.7 months in patients receiving chemotherapy/osimertinib as subsequent therapy. The most common treatment-related adverse events (TRAEs; any grade/grade ≥3) were diarrhea (31.3%/8.5%) and rash (23.0%/8.1%). Overall, 34 patients (8.1%) discontinued afatinib due to AEs.

Conclusions

Afatinib was well tolerated with no new safety signals, and efficacy was encouraging in Korean patients with EGFRm⁺ NSCLC, including those with baseline brain metastases and/or uncommon EGFR mutations. AE management with dose reductions facilitated a long TTD, prolonging the chemotherapy-free period for many patients.

SUBMITTER: Lee SY

PROVIDER: S-EPMC8743522 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Real-world experience of afatinib as first-line therapy for advanced <i>EGFR</i> mutation-positive non-small cell lung cancer in Korea.

Lee Sung Yong SY Choi Chang-Min CM Chang Yoon Soo YS Lee Kye Young KY Kim Seung Joon SJ Yang Sei Hoon SH Ryu Jeong Seon JS Lee Jeong Eun JE Lee Shin Yup SY Park Ji Young JY Kim Young-Chul YC Oh In-Jae IJ Jung Chi Young CY Lee Sang Hoon SH Yoon Seong Hoon SH Choi Juwhan J Jang Tae Won TW

Translational lung cancer research 20211201 12

<h4>Background</h4>We investigated the clinical characteristics and treatment outcomes of Korean patients receiving first-line afatinib for advanced epidermal growth factor receptor mutation-positive (<i>EGFR</i>m<sup>+</sup>) non-small cell lung cancer (NSCLC) in a real-world setting.<h4>Methods</h4>Electronic case reports were retrospectively reviewed from patients across 15 sites in South Korea. Outcome measures included baseline characteristics, overall response rate (ORR), time-to-treatment ...[more]

PMID: 35070746

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