Genome-wide analysis study of gestational diabetes mellitus and related pathogenic factors in a Chinese Han population.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) affects the metabolism of both the mother and fetus during and after pregnancy. Genetic factors are important in the pathogenesis of GDM, and associations vary by ethnicity. However, related studies about the relationship between the susceptibility genes and glucose traits remain limited in China. This study aimed to identify genes associated with GDM susceptibility in Chinese Han women and validate those findings using clinical data during pregnancy and postpartum period.

Methods

A genome-wide association study (GWAS) of 398 Chinese Han women (199 each with and without GDM) was conducted and associations between single nucleotide polymorphisms (SNPs) and glucose metabolism were identified by searching public databases. Relation

SUBMITTER: Yue S 

PROVIDER: S-EPMC10714520 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature