An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity.

ABSTRACT:

Rationale

Type 2 diabetes (T2D) costs billions of dollars annually, is also associated with pain (diabetic neuropathy), as well as retinopathy, lower urinary tract/urinary bladder dysfunction, depression, and systemic inflammation, affecting quality of life for patients. To that end, animal models are utilized to explore potential treatments, but may not reflect the complexity of the condition.

Objective

We aimed to test an improved model of T2D that more closely mimics the clinical mechanisms and symptoms in an outbred strain of mouse.

Findings

Male and female CD-1 mice (n = 72) were fed one of four diets: regular chow (REG), our Standard American Diet (SAD), a revised SAD (SAD2), or the commonly-used high-fat diet (HFD). Overall, HFD- and SAD-fed mice had significan

SUBMITTER: Wiggins AM 

PROVIDER: S-EPMC10714886 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature