SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts.

ABSTRACT:

Background

The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease's extensive and sustained symptoms are now becoming a nonnegligible medical challenge. In this respect, data indicate that heart failure is one of the most common readmission diagnoses among COVID-19 patients.

Methods

In this study, we used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes to develop an in vitro model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and studied the dynamic changes occurring in cardiomyocytes after SARS-CoV-2 infection.

Results

To this end, we have created an effective time series SARS-CoV-2 infection model exhibiting different functional patterns of up- and dow

SUBMITTER: Li X 

PROVIDER: S-EPMC10717444 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature