Dynamic altruistic cooperation within breast tumors.

ABSTRACT:

Background

Social behaviors such as altruism, where one self-sacrifices for collective benefits, critically influence an organism's survival and responses to the environment. Such behaviors are widely exemplified in nature but have been underexplored in cancer cells which are conventionally seen as selfish competitive players. This multidisciplinary study explores altruism and its mechanism in breast cancer cells and its contribution to chemoresistance.

Methods

MicroRNA profiling was performed on circulating tumor cells collected from the blood of treated breast cancer patients. Cancer cell lines ectopically expressing candidate miRNA were used in co-culture experiments and treated with docetaxel. Ecological parameters like relative survival and relative fitness were assesse

SUBMITTER: Masroni MSB 

PROVIDER: S-EPMC10720132 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature