Antibiotic resistance, bacterial transmission and improved prediction of bacterial infection in patients with antibody deficiency.

ABSTRACT:

Background

Antibody-deficient patients are at high risk of respiratory tract infections. Many therefore receive antibiotic prophylaxis and have access to antibiotics for self-administration in the event of breakthrough infections, which may increase antimicrobial resistance (AMR).

Objectives

To understand AMR in the respiratory tract of patients with antibody deficiency.

Methods

Sputum samples were collected from antibody-deficient patients in a cross-sectional and prospective study; bacteriology culture, 16S rRNA profiling and PCR detecting macrolide resistance genes were performed. Bacterial isolates were identified using MALDI-TOF, antimicrobial susceptibility was determined by disc diffusion and WGS of selected isolates was done using Illumina NextSeq with analysi

SUBMITTER: Rofael S 

PROVIDER: S-EPMC10720947 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature