The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.

ABSTRACT: The importance of nicotinamide adenine dinucleotide (NAD⁺) in human physiology is well recognized. As the NAD⁺ concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD⁺ status could possibly influence the aging process and associated metabolic sequelae. Nicotinamide mononucleotide (NMN) is a precursor for NAD⁺ biosynthesis, and in vitro/in vivo studies have demonstrated that NMN supplementation increases NAD⁺ concentration and could mitigate aging-related disorders such as oxidative stress, DNA damage, neurodegeneration, and inflammatory responses. The promotion of NMN as an antiaging health supplement has gained popularity due to such findings; however, since most stud

SUBMITTER: Song Q 

PROVIDER: S-EPMC10721522 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature