Pressure-support compared with pressure-controlled ventilation mitigates lung and brain injury in experimental acute ischemic stroke in rats.

ABSTRACT:

Background

We aimed to evaluate the pulmonary and cerebral effects of low-tidal volume ventilation in pressure-support (PSV) and pressure-controlled (PCV) modes at two PEEP levels in acute ischemic stroke (AIS).

Methods

In this randomized experimental study, AIS was induced by thermocoagulation in 30 healthy male Wistar rats. After 24 h, AIS animals were randomly assigned to PSV or PCV with V_T = 6 mL/kg and PEEP = 2 cmH₂O (PSV-PEEP2 and PCV-PEEP2) or PEEP = 5 cmH₂O (PSV-PEEP5 and PCV-PEEP5) for 2 h. Lung mechanics, arterial blood gases, and echocardiography were evaluated before and after the experiment. Lungs and brain tissue were removed for histologic and molecular biology analysis. The primary endpoint was diffuse alveolar damage (DAD) sc

SUBMITTER: da Silva AL 

PROVIDER: S-EPMC10724101 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature