Sono-Activatable Semiconducting Polymer Nanoreshapers Multiply Remodel Tumor Microenvironment for Potent Immunotherapy of Orthotopic Pancreatic Cancer.

ABSTRACT: Due to the complicated tumor microenvironment that compromises the efficacies of various therapies, the effective treatment of pancreatic cancer remains a big challenge. Sono-activatable semiconducting polymer nanoreshapers (SPN_DN H) are constructed to multiply remodel tumor microenvironment of orthotopic pancreatic cancer for potent immunotherapy. SPN_DN H contain a semiconducting polymer, hydrogen sulfide (H₂ S) donor, and indoleamine 2,3-dioxygenase (IDO) inhibitor (NLG919), which are encapsulated by singlet oxygen (¹ O₂ )-responsive shells with modification of hyaluronidase (HAase). After accumulation in orthotopic pancreatic tumor sites, SPN_DN H degrade the major content of tumor microenvironment hyaluronic acid to promo

SUBMITTER: Li M 

PROVIDER: S-EPMC10724419 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature