Microgravity triggers ferroptosis and accelerates senescence in the MG-63 cell model of osteoblastic cells.

ABSTRACT: In space, cells sustain strong modifications of their mechanical environment. Mechanosensitive molecules at the cell membrane regulate mechanotransduction pathways that induce adaptive responses through the regulation of gene expression, post-translational modifications, protein interactions or intracellular trafficking, among others. In the current study, human osteoblastic cells were cultured on the ISS in microgravity and at 1 g in a centrifuge, as onboard controls. RNAseq analyses showed that microgravity inhibits cell proliferation and DNA repair, stimulates inflammatory pathways and induces ferroptosis and senescence, two pathways related to ageing. Morphological hallmarks of senescence, such as reduced nuclear size and changes in chromatin architecture, proliferation marker distribu

SUBMITTER: Garbacki N 

PROVIDER: S-EPMC10725437 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature