Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine.

ABSTRACT:

Objective

Advanced mass spectrometry methods were leveraged to analyze both proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and hemorrhagic shock (HS)-isolated or combined-in a swine model, followed by correlation to viscoelastic measurements of coagulopathy via thrombelastography.

Background

TI and HS cause distinct molecular changes in plasma in both animal models and trauma patients. However, the contribution to coagulopathy of trauma, the leading cause of preventable mortality in this patient population remains unclear. The recent development of a swine model for isolated or combined TI+HS facilitated the current study.

Methods

Male swine (n=17) were randomized to either isolated or combined TI and HS. Coagulation status was ana

SUBMITTER: LaCroix IS 

PROVIDER: S-EPMC10728352 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature