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Targeting NAD⁺ metabolism: dual roles in cancer treatment.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is indispensable for various oxidation-reduction reactions in mammalian cells, particularly during energy production. Malignant cells increase the expression levels of NAD⁺ biosynthesis enzymes for rapid proliferation and biomass production. Furthermore, mounting proof has indicated that NAD-degrading enzymes (NADases) play a role in creating the immunosuppressive tumor microenvironment (TME). Interestingly, both inhibiting NAD⁺ synthesis and targeting NADase have positive implications for cancer treatment. Here we summarize the detrimental outcomes of increased NAD⁺ production, the functions of NAD⁺ metabolic enzymes in creating an immunosuppressive TME, and discuss the progress and clinical translational potential of inhibitors for NAD⁺ synthesis and therapies targeting NADase.

SUBMITTER: Yong J

PROVIDER: S-EPMC10728650 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Targeting NAD+ metabolism: dual roles in cancer treatment.

Yong Jiaxin J Cai Songqing S Zeng Zhaolei Z

Frontiers in immunology 20231205

Nicotinamide adenine dinucleotide (NAD+) is indispensable for various oxidation-reduction reactions in mammalian cells, particularly during energy production. Malignant cells increase the expression levels of NAD+ biosynthesis enzymes for rapid proliferation and biomass production. Furthermore, mounting proof has indicated that NAD-degrading enzymes (NADases) play a role in creating the immunosuppressive tumor microenvironment (TME). Interestingly, both inhibiting NAD+ ...[more]

PMID: 38116009

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