1,4,7-Triazacyclononane-Based Chelators for the Complexation of [¹⁸⁶Re]Re- and [^99mTc]Tc-Tricarbonyl Cores.

ABSTRACT: Metal complexes with the general formula [M^I(CO)₃(k³-L)]⁺, where M = Re, ¹⁸⁶Re, or ^99mTc and L = 1,4,7-triazacyclononane (TACN), NOTA, or NODAGA chelators, have previously been conjugated to peptide-based biological targeting vectors and investigated as potential theranostic radiopharmaceuticals. The promising results demonstrated by these bioconjugate complexes prompted our exploration of other TACN-based chelators for suitability for (radio)labeling with the [M(CO)₃]⁺ core. In this work, we investigated the role of the TACN pendant arms in complexation of the [M(CO)₃]⁺ core through (radio)labeling of TACN chelators bearing acid, ester, mixed acid-ester, or no pendant functional g

SUBMITTER: Hoerres R 

PROVIDER: S-EPMC10732151 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature