Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study.

ABSTRACT:

Background

Oxycodone active uptake across the blood-brain barrier (BBB) is associated with the putative proton-coupled organic cation (H⁺/OC) antiporter system. Yet, the activity of this system at the blood-cerebrospinal fluid barrier (BCSFB) is not fully understood. Additionally, sex differences in systemic pharmacokinetics and pharmacodynamics of oxycodone has been reported, but whether the previous observations involve sex differences in the function of the H⁺/OC antiporter system remain unknown. The objective of this study was, therefore, to investigate the extent of oxycodone transport across the BBB and the BCSFB in female and male Sprague-Dawley rats using microdialysis.

Methods

Microdialysis probes were implanted in the blood and two of the foll

SUBMITTER: Ballgren F 

PROVIDER: S-EPMC10733202 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature