Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry.

ABSTRACT:

Introduction

Despite established knowledge on the morphological and functional asymmetries in the human brain, the understanding of how brain asymmetry patterns change during late fetal to neonatal life remains incomplete. The goal of this study was to characterize the dynamic patterns of inter-hemispheric brain asymmetry over this critically important developmental stage using longitudinally acquired MRI scans.

Methods

Super-resolution reconstructed T2-weighted MRI of 20 neurotypically developing participants were used, and for each participant fetal and neonatal MRI was acquired. To quantify brain morphological changes, deformation-based morphometry (DBM) on the longitudinal MRI scans was utilized. Two registration frameworks were evaluated and used in our study: (A) fetal

SUBMITTER: Steger C 

PROVIDER: S-EPMC10734644 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature