REDOX Balance in Oligodendrocytes Is Important for Zebrafish Visual System Regeneration.

ABSTRACT: Zebrafish (Danio rerio) present continuous growth and regenerate many parts of their body after an injury. Fish oligodendrocytes, microglia and astrocytes support the formation of new connections producing effective regeneration of the central nervous system after a lesion. To understand the role of oligodendrocytes and the signals that mediate regeneration, we use the well-established optic nerve (ON) crush model. We also used sox10 fluorescent transgenic lines to label fully differentiated oligodendrocytes. To quench the effect of reactive oxygen species (ROS), we used the endogenous antioxidant melatonin. Using these tools, we measured ROS production by flow cytometry and explored the regeneration of the optic tectum (OT), the response of oligodendrocytes and their mitocho

SUBMITTER: Perez-Montes C 

PROVIDER: S-EPMC10740785 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature